Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.

Autor: Li Q; Department of Psychiatry, The University of Hong Kong, Hong Kong, China.; State Key Laboratory for Cognitive and Brain Sciences, The University of Hong Kong, Hong Kong, China.; HKU-SIRI, The University of Hong Kong, Hong Kong, China., Leung YO; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Zhou I; Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China.; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China., Ho LC; Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China.; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China., Kong W; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Basil P; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Wei R; Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, China., Lam S; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Zhang X; Department of Neurology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Law AC; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Chua SE; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Sham PC; Department of Psychiatry, The University of Hong Kong, Hong Kong, China.; State Key Laboratory for Cognitive and Brain Sciences, The University of Hong Kong, Hong Kong, China.; Centre for Reproduction, Development and Growth, The University of Hong Kong, Hong Kong, China.; Genome Research Centre, The University of Hong Kong, Hong Kong, China., Wu EX; Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China.; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China., McAlonan GM; Department of Psychiatry, The University of Hong Kong, Hong Kong, China.; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2015 Sep 22; Vol. 5, pp. e641. Date of Electronic Publication: 2015 Sep 22.
DOI: 10.1038/tp.2015.126
Abstrakt: Prenatal exposure to maternal immune activation (MIA) increases the risk of schizophrenia and autism in the offspring. The MIA rodent model provides a valuable tool to directly test the postnatal consequences of exposure to an early inflammatory insult; and examine novel preventative strategies. Here we tested the hypotheses that behavioural differences in the MIA mouse model are accompanied by in vivo and ex vivo alterations in brain biochemistry; and that these can be prevented by a post-weaning diet enriched with n-3 polyunsaturated fatty acid (PUFA). The viral analogue PolyI:C (POL) or saline (SAL) was administered to pregnant mice on gestation day 9. Half the resulting male offspring (POL=21; SAL=17) were weaned onto a conventional lab diet (n-6 PUFA); half were weaned onto n-3 PUFA-enriched diet. In vivo magnetic resonance spectroscopy measures were acquired prior to behavioural tests; glutamic acid decarboxylase 67 (GAD67) and tyrosine hydroxylase protein levels were measured ex vivo. The main findings were: (i) Adult MIA-exposed mice fed a standard diet had greater N-acetylaspartate/creatine (Cr) and lower myo-inositol/Cr levels in the cingulate cortex in vivo. (ii) The extent of these metabolite differences was correlated with impairment in prepulse inhibition. (iii) MIA-exposed mice on the control diet also had higher levels of anxiety and altered levels of GAD67 ex vivo. (iv) An n-3 PUFA diet prevented all the in vivo and ex vivo effects of MIA observed. Thus, n-3 PUFA dietary enrichment from early life may offer a relatively safe and non-toxic approach to limit the otherwise persistent behavioural and biochemical consequences of prenatal exposure to inflammation. This result may have translational importance.
Databáze: MEDLINE
Externí odkaz: