Changes in the Morphological and Immunological Characteristics of Mel Ibr Melanoma Cells in Response to Chicken Embryo Extract.

Autor: Suraeva NM; N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. nsuraeva@yandex.ru., Morozova LF; N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia., Samoilov AV; All-Russian Research Institute of Preservation Technology, Moscow Region, Vidnoe, Russia., Burova OS; N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia., Golubeva VA; N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia., Baryshnikova MA; N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia., Baryshnikov AY; N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Aug; Vol. 159 (4), pp. 520-3. Date of Electronic Publication: 2015 Sep 21.
DOI: 10.1007/s10517-015-3007-5
Abstrakt: Exposure of Mel Ibr human melanoma cells to chicken embryo extract resulted in the appearance of a subclone with morphological and growth characteristics similar to those of embryonic stem cells. The subclone differed from the parental line cells by a sharply reduced percentage of HLA-DR(+) and CD54(+) cells, a significantly elevated percentage of CD63(+) cells, and appearance of CD133(+) and Oct-4A(+) cells. Hence, the subclone cells were characterized by the same features as stem tumor cells and could be responsible for further progress of tumor growth.
Databáze: MEDLINE
Externí odkaz: