| Autor: |
Al-Sayed E; a Department of Pharmacognosy, Faculty of Pharmacy , Ain-Shams University , Cairo , Egypt ., Abdel-Daim MM; b Department of Pharmacoloy, Faculty of Veterinary Medicine , Suez Canal University , Ismailia , Egypt ., Kilany OE; c Department of Clinical Pathology, Faculty of Veterinary Medicine , Suez Canal University , Ismailia , Egypt , and., Karonen M; d Laboratory of Organic Chemistry and Chemical Biology, Department of Chemistry, University of Turku , Turku , Finland., Sinkkonen J; d Laboratory of Organic Chemistry and Chemical Biology, Department of Chemistry, University of Turku , Turku , Finland. |
| Jazyk: |
angličtina |
| Zdroj: |
Renal failure [Ren Fail] 2015 Aug; Vol. 37 (7), pp. 1198-207. Date of Electronic Publication: 2015 Jul 06. |
| DOI: |
10.3109/0886022X.2015.1061886 |
| Abstrakt: |
The hepatoprotective and nephroprotective activity of a polyphenol-rich fraction (BHPF) obtained from Bauhinia hookeri was investigated against CCl4-induced acute hepatorenal toxicity in mice. BHPF was administered (100, 200 and 400 mg/kg/day) for 5 days, then CCl4 was administered. BHPF pretreatment significantly (p < 0.001) inhibited the CCl4-induced increase in ALT, AST, ALP, LDH, total bilirubin, cholesterol, creatinine, uric acid, urea and malondialdehyde in a dose-dependent manner. In contrast, BHPF pretreatment markedly increased the contents of glutathione and superoxide dismutase in the liver and kidney tissues, indicating the strong in vivo antioxidant activity of BHPF. Pretreatment with BHPF preserved the hepatic architecture and conferred marked protection against necrosis and ballooning degeneration. Pretreatment with BHPF reduced the inflammatory cell aggregation and degenerative changes in the lining epithelium of the kidney tubules. It can be concluded that BHPF has a remarkable hepato- and nephroprotective activity by enhancing the antioxidant defense status, reducing lipid peroxidation and protecting against the histopathological changes induced by CCl4 in the liver and kidney tissues. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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