Deleterious Germline BLM Mutations and the Risk for Early-onset Colorectal Cancer.

Autor:	de Voer RM; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Hahn MM; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Mensenkamp AR; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Hoischen A; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Gilissen C; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Henkes A; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Spruijt L; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., van Zelst-Stams WA; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Kets CM; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Verwiel ET; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Nagtegaal ID; Department of Pathology, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Schackert HK; Department of Surgical Research, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany., van Kessel AG; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Hoogerbrugge N; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Ligtenberg MJ; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands.; Department of Pathology, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands., Kuiper RP; Department of Human Genetics, Radboud university medical center, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2015 Sep 11; Vol. 5, pp. 14060. Date of Electronic Publication: 2015 Sep 11.
DOI:	10.1038/srep14060
Abstrakt:	Bloom syndrome is an autosomal recessive disorder characterized by chromosomal instability and increased cancer risk, caused by biallelic mutations in the RECQL-helicase gene BLM. Previous studies have led to conflicting conclusions as to whether carriers of heterozygous BLM mutations have an increased risk to develop colorectal cancer (CRC). We recently identified two carriers of a pathogenic BLM mutation in a cohort of 55 early-onset CRC patients (≤45 years of age), suggesting an overrepresentation compared to the normal population. Here, we performed targeted sequencing using molecular inversion probes to screen an additional cohort of 185 CRC patients (≤50 years of age) and 532 population-matched controls for deleterious BLM mutations. In total, we identified three additional CRC patients (1.6%) and one control individual (0.2%) that carried a known pathogenic BLM mutation, suggesting that these mutations are enriched in early-onset CRC patients (P = 0.05516). A comparison with local and publically available databases from individuals without suspicion for hereditary cancer confirmed this enrichment (P = 0.003534). Analysis of family members of the five BLM mutation carriers with CRC suggests an incomplete penetrance for CRC development. Therefore, these data indicate that carriers of deleterious BLM mutations are at increased risk to develop CRC, albeit with a moderate-to-low penetrance.
Databáze:	MEDLINE
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