| Autor: |
Geretti AM; University of Liverpool, Liverpool, UK., Moeketsi M; Folateng Ward, Sebokeng Hospital, Gauteng, South Africa., Demasi R; Janssen Research and Development, LLC, Titusville, NJ, USA., van Delft Y; Janssen Global Public Health, Tilburg, Netherlands., Mohammed P; Janssen Global Public Health, High Wycombe, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
AIDS research and treatment [AIDS Res Treat] 2015; Vol. 2015, pp. 962574. Date of Electronic Publication: 2015 Aug 18. |
| DOI: |
10.1155/2015/962574 |
| Abstrakt: |
Background. An exploratory subanalysis of the ODIN trial was performed to evaluate the efficacy of darunavir/ritonavir (DRV/r) 800/100 mg OD versus 600/100 mg BID in patients who were NNRTI-experienced but PI-naïve. Methods. ODIN was a phase III, 48-week study comparing DRV/r OD versus BID in 590 treatment-experienced patients with no DRV resistance-associated mutations (RAMs) at screening. Patients received DRV/r 800/100 mg OD or DRV/r 600/100 mg BID plus ≥2 NRTIs. Of the 590 patients randomized, 272 (46%) were NNRTI-experienced but PI-naïve. Results. Overall, 272 patients received DRV/r OD (n = 135) or BID (n = 137) plus ≥2 optimised NRTIs. The mean age was 39 years; 35% were female; 27% were Black, 24% Caucasian, 26% Oriental/Asian, and 23% other races; 17% were recruited in South Africa; and 48% had non-B HIV-1 subtypes. Mean baseline plasma HIV-1 RNA load was 4.10 log10 copies/mL; median CD4 cell count was 258 cells/μL. At week 48, 111/135 (82%) of DRV/r OD and 109/137 (80%) of DRV/r BID patients achieved an HIV-1 RNA load <50 copies/mL. No patient developed primary PI RAMs. Conclusion. DRV/r 800/100 mg OD in combination with ≥2 optimised NRTIs led to virological suppression <50 copies/mL in 82% of NNRTI-experienced, PI-naïve patients by week 48. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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