[The relationship between neuroendocrine dysfunction and free-radical oxidation in old age alcoholism].

Autor:	Vinogradov DB; Chelyabinsk Regional Clinical Narcological Hospital Drug, Chelyabinsk., Mingazov AK; South Ural State Medical University, Chelyabinsk., Izarovskaya IV; South Ural State University, Chelyabinsk., Babin KA; Chelyabinsk Regional Clinical Narcological Hospital Drug, Chelyabinsk., Sinitsky AI; South Ural State Medical University, Chelyabinsk.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2015; Vol. 115 (8), pp. 73-75.
DOI:	10.17116/jnevro20151158173-75
Abstrakt:	Objective: to study the relationship between dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and free-radical oxidation in old age alcoholism. Material and Methods: Authors examined 46 men and women, aged 60-80 years, with alcoholism. Contents of cortisol, lipid peroxidation products and the level of an oxidatively modified protein were measured. Results and Conclusion: A decrease in blood cortisol content and correlations between its level and activity of free-radical oxidation were identified. The severity of neuroendocrine dysfunction in old patients was sex-related. It has been suggested that the impairment of HPA system activity may be a cause of oxidative stress and development of alcoholism.
Databáze:	MEDLINE
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