A longitudinal study of changes in Diffusion Tensor Value and their association with cognitive sequelae among patients with mild head injury.

Autor:	Munivenkatappa A; Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bangalore, India., Bhagavatula ID; Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India - drindiradb@gmail.com., Shukla DP; Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India., Rajeswaran J; Department of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Jazyk:	angličtina
Zdroj:	Journal of neurosurgical sciences [J Neurosurg Sci] 2017 Jun; Vol. 61 (3), pp. 283-290. Date of Electronic Publication: 2015 Sep 09.
DOI:	10.23736/S0390-5616.16.03112-X
Abstrakt:	Background: Diffusion tensor imaging (DTI) is an advanced and sensitive technique that detects sub-threshold pathology in normal imaging brain injury patients. Currently, there are no longitudinal DTI studies to look for time-based changes. The present study has investigated longitudinal imaging and its association with cognitive deficits. Methods: Twenty-one patients were available for MRI and neuropsychological test (NPT) assessment for all the 3 time points. Initially (<36 hours), all patients presented with GCS 15 and normal scan findings. The DTI (P<0.0001) and NPT scores (P<0.05) were analyzed using repeated-measure of analysis. The tensor values were correlated with specific time-point NPT scores using partial correlation (0.05). Results: Right cerebral-hemisphere showed significant alterations in both anisotropy and diffusivity values overtime. Cingulate gyrus and occipital lobe showed prominent changes in anisotropy value. Significant improvement in thalamo-cortical anisotropy value after 3-4 months after injury was seen. The changes in diffusivity values were mainly seen in frontal, parietal lobe, right inferior fronto-occipital and superior longitudinal fasciculus, and posterior supramarginal gyrus. Time-related changes of tensor values of thalamus, frontal and temporal lobe had persistent and significant association with attention and learning/memory aspects. Conclusions: The findings of this study suggest that DTI detects and observes natural-recovery of brain regions affected by sub-threshold force.
Databáze:	MEDLINE
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