| Autor: |
Walker SL; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom., Balagon M; Leonard Wood Memorial Center for TB and Leprosy Research, Cebu, Philippines., Darlong J; The Leprosy Mission Hospital, Purulia, India., Doni SN; ALERT Center, Addis Ababa, Ethiopia., Hagge DA; Anandaban Hospital, Kathmandu, Nepal., Halwai V; Bombay Leprosy Project, Mumbai, India., John A; The Leprosy Mission Trust India, New Delhi, India., Lambert SM; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; ALERT Center, Addis Ababa, Ethiopia., Maghanoy A; Leonard Wood Memorial Center for TB and Leprosy Research, Cebu, Philippines., Nery JA; FIOCRUZ, Rio de Janeiro, Brazil., Neupane KD; Anandaban Hospital, Kathmandu, Nepal., Nicholls PG; University of Southampton, Southampton, United Kingdom., Pai VV; Bombay Leprosy Project, Mumbai, India., Parajuli P; Anandaban Hospital, Kathmandu, Nepal., Sales AM; FIOCRUZ, Rio de Janeiro, Brazil., Sarno E; FIOCRUZ, Rio de Janeiro, Brazil., Shah M; Anandaban Hospital, Kathmandu, Nepal., Tsegaye D; ALERT Center, Addis Ababa, Ethiopia., Lockwood DN; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. |
| Abstrakt: |
Erythema nodosum leprosum (ENL) is a severe multisystem immune mediated complication of borderline lepromatous leprosy and lepromatous leprosy. ENL is associated with skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. The treatment of ENL requires immunosuppression, which is often required for prolonged periods of time and may lead to serious adverse effects. ENL and its treatment is associated with increased mortality and economic hardship. Improved, evidence-based treatments for ENL are needed; however, defining the severity of ENL and outcome measures for treatment studies is difficult because of the multiple organ systems involved. A cross-sectional study was performed, by the members of the Erythema Nodosum Leprosum International STudy (ENLIST) Group, of patients with ENL attending seven leprosy referral centres in Brazil, Ethiopia, India, Nepal, the Philippines and the United Kingdom. We systematically documented the clinical features and type of ENL, its severity and the drugs used to treat it. Patients with chronic ENL were more likely to be assessed as having severe ENL. Pain, the most frequent symptom, assessed using a semi-quantitative scale was significantly worse in individuals with "severe" ENL. Our findings will determine the items to be included in a severity scale of ENL which we are developing and validating. The study also provides data on the clinical features of ENL, which can be incorporated into a definition of ENL and used for outcome measures in treatment studies. |
