Glutathione S-transferase M1 and T1 gene polymorphisms in Brazilian women with endometriosis.

Autor: Kubiszeski EH; Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil. eloisahelenak@yahoo.com.br.; Av. Fernando Corrêa da Costa, n° 2367-Bairro Boa Esperança, Cuiabá, MT, ZIPMAIL: 78060-900, Brazil. eloisahelenak@yahoo.com.br., de Medeiros SF; Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil.; Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil.; Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, MT, Brazil., da Silva Seidel JA; Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil., Barbosa JS; Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil., Galera MF; Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil.; Department of Basic Sciences, Medical School, Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil., Galera BB; Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil.; Department of Basic Sciences, Medical School, Federal University of Mato Grosso-UFMT, Cuiabá, MT, Brazil.
Jazyk: angličtina
Zdroj: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2015 Oct; Vol. 32 (10), pp. 1531-5. Date of Electronic Publication: 2015 Sep 09.
DOI: 10.1007/s10815-015-0554-7
Abstrakt: Purpose: The glutathione family (GST) genes appear to play a role in the genesis of endometriosis. This case-control study aimed to compare the frequencies of GSTM1 and GSTT1 polymorphisms in women with endometriosis and women without endometriosis.
Methods: Polymerase chain reaction was performed to analyze the GSTM1 and GSTT1 genotypes among women with surgically and histologically confirmed endometriosis (case group n = 121) and in women without evidence of endometriosis confirmed by laparoscopy for investigation the infertility or for laparoscopic tubal sterilization (control group n = 97).
Result(s): No differences in the frequencies of GSTM1 polymorphism (null genotype) were observed between the cases and controls: odds ratio (OR) = 1.13; 95 % CI 0.656-1.93 (p = 0.659). The GSTT1 polymorphism (null genotype) was more prevalent in the endometriosis group than in the control group (OR = 0.53; 95 % CI 0.94-0.29 (p = 0.039). No relationship between menstrual cycle interval and GSTM1 null genotype frequency was observed in either cases or controls (p = 0.370 and p = 0.664, respectively). In addition, no relationship between menstrual cycle interval and GSTT1 null genotype was observed in cases (p = 0.797) or controls (p = 0.052).
Conclusions: GSTM1 null genotype frequency was similar between cases and controls. The GSTT1 null genotype was more frequent in the control group.
Databáze: MEDLINE
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