| Autor: |
Al-Qadhi BN; Biology Department, College of Science, University of Baghdad, Baghdad, Iraq., Musa IS; Biology Department, College of Science, University of Baghdad, Baghdad, Iraq., Al-Mulla Hummadi YM; Department of Pharmacology and Toxicology, College of Pharmacy, Al-Mustansiriyah-University, Baghdad, Iraq. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of parasitic diseases : official organ of the Indian Society for Parasitology [J Parasit Dis] 2015 Sep; Vol. 39 (3), pp. 361-70. Date of Electronic Publication: 2013 Nov 21. |
| DOI: |
10.1007/s12639-013-0368-4 |
| Abstrakt: |
Ninety-five Iraqi patients with cutaneous leishmaniasis (CL) caused by Leishmania tropica at AL-Karama Hospital in Baghdad were included in this study. Sixty patients were with single sore and the remaining with multiple sores. The study also included 10 atopic patients and 30 healthy individuals as a control group. Cellular and humoral immune response at different stages of the disease activity (early and late) were evaluated by estimation of serum IFN-γ, IL-4 and total IgE antibodies using ELISA kits while, the detection of specific anti leishmanial IgE antibodies was done manually. Specific IgE antibodies were only detected in early CL (<2 months) patients 68 (71.57 %) while, were not detected in late CL, atopic and healthy controls 30 (100 %). The results also showed a positive relationship between this antibody and the number of sores. Th-2 predominates during the early stage of the disease then shifts to Th-1 that proceed in the late stage, but both cytokines increased in CL patients in comparison to control group. The immune response of CL infection is possibly regulated by both Th-1 and Th-2. Multiple sores patients showed an increase of anti leishmanial IgE (0.120 ± 0.014), total IgE (120.7 ± 39.58 IU/ml), IFN-γ (87.4 ± 30.52 pg/ml) and IL-4 (63.70 ± 20.32 pg/ml) levels than single sore patients with mean value of 0.108 ± 0.14, 92.3 ± 35.23 IU/ml, 47.2 ± 27.80 pg/ml and 51.04 ± 15.0 pg/ml respectively. It can be presented also as ratio of INF-γ/IL-4 = 1.37 which is greater than those for single sore 0.9. These results indicated that the immune response of multiple sores patient's is higher than that with single sores. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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