Peripheral inflammation during abnormal mood states in bipolar I disorder.

Autor: Fiedorowicz JG; Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, 52242, USA. Electronic address: jess-fiedorowicz@uiowa.edu., Prossin AR; Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA., Johnson CP; Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA., Christensen GE; Department of Radiation Oncology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA; Department of Electrical and Computer Engineering, College of Engineering, The University of Iowa, Iowa City, IA, 52242, USA., Magnotta VA; Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA; Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA., Wemmie JA; Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA; Veterans Affairs Hospital Center, Iowa City, IA, USA.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2015 Nov 15; Vol. 187, pp. 172-8. Date of Electronic Publication: 2015 Aug 21.
DOI: 10.1016/j.jad.2015.08.036
Abstrakt: Background: Bipolar disorder carries a substantive morbidity and mortality burden, particularly related to cardiovascular disease. Abnormalities in peripheral inflammatory markers, which have been commonly reported in case-control studies, potentially link these co-morbidities. However, it is not clear whether inflammatory markers change episodically in response to mood states or are indicative of chronic pro-inflammatory activity, regardless of mood, in bipolar disorder.
Methods: Investigations focused on comparing concentrations of specific inflammatory cytokines associated with immune activation status (primary outcome=tumor necrosis factor alpha (TNF-α)) in 37 participants with bipolar disorder across 3 mood states (mania N=15, depression N=9, normal mood N=13) and 29 controls without a psychiatric disorder (total N=66). Cytokine levels were also compared to T1ρ, a potential neuroimaging marker for inflammation, in select brain regions in a subsample (N=39).
Results: Participants with bipolar disorder and healthy controls did not differ significantly in inflammatory cytokine concentrations. However, compared to cases with normal mood, cases with abnormal mood states (mania and depression) had significantly elevated levels of TNF-α, its soluble receptors (sTNFR1/sTNFR2), other macrophage-derived cytokines (interleukin 1β (IL-1β), IL-6, IL-10, and IL-18) in addition to IL-4, interferon-γ, monocyte chemotactic protein-1, fibroblast growth factor β, and vascular endothelial growth factor. Cytokine levels were not correlated with signals from T1ρ imaging in selected structures (amygdalae, hippocampi, hypothalamus, anterior cingulate gyrus, and middle frontal gyrus).
Limitations: Participants were not followed prospectively across mood states.
Conclusion: Activation of inflammatory markers was found in abnormal mood states of bipolar disorder. Longitudinal study of individuals with mood disorders is needed to confirm these findings and to elucidate the time course of any such changes.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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