Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.

Autor:	Marandu TF; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany Dar es Salaam University College of Education, Dar es Salaam, Tanzania., Oduro JD; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany., Borkner L; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany., Dekhtiarenko I; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany., Uhrlaub JL; Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, USA., Drabig A; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany., Kröger A; Research Group Innate Immunity and Infection, HZI, Braunschweig, Germany., Nikolich-Zugich J; Oregon Health and Science University (OHSU), Portland, Oregon, USA Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, USA., Cicin-Sain L; Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany Institute for Virology, Medical School Hannover, Hanover, Germany luka.cicin-sain@helmholtz-hzi.de.
Jazyk:	angličtina
Zdroj:	Journal of virology [J Virol] 2015 Nov; Vol. 89 (22), pp. 11715-7. Date of Electronic Publication: 2015 Sep 02.
DOI:	10.1128/JVI.01989-15
Abstrakt:	Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients. (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
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