Elevated Plasma C-Terminal Endothelin-1 Precursor Fragment Concentrations Are Associated with Less Anxiety in Patients with Cardiovascular Risk Factors. Results from the Observational DIAST-CHF Study.

Autor: Meyer T; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Göttingen, Germany; German Centre for Cardiovascular Research, partner site Göttingen, Göttingen, Germany., Chavanon ML; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Göttingen, Germany; German Centre for Cardiovascular Research, partner site Göttingen, Göttingen, Germany., Herrrmann-Lingen C; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Göttingen, Germany; German Centre for Cardiovascular Research, partner site Göttingen, Göttingen, Germany., Roggenthien M; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Göttingen, Germany., Nolte K; Department of Cardiology and Pneumology, University of Göttingen, Göttingen, Germany., Pieske B; Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany; German Center for Cardiovascular Research, partner site Berlin, Berlin, Germany., Wachter R; Department of Cardiology and Pneumology, University of Göttingen, Göttingen, Germany; German Center for Cardiovascular Research, partner site Berlin, Berlin, Germany., Edelmann F; Department of Cardiology and Pneumology, University of Göttingen, Göttingen, Germany; Department of Internal Medicine and Cardiology, Charité University Medicine, Berlin, Germany; German Center for Cardiovascular Research, partner site Berlin, Berlin, Germany.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2015 Aug 31; Vol. 10 (8), pp. e0136739. Date of Electronic Publication: 2015 Aug 31 (Print Publication: 2015).
DOI: 10.1371/journal.pone.0136739
Abstrakt: Background: The role of endothelin-1 (ET-1) in the neurobiology of anxiety is unknown, therefore, we assessed in the observational multicenter DIAST-CHF study whether the C-terminal ET-1 precursor fragment (CT-proET-1) is linked to anxiety.
Methods: Plasma concentrations of CT-proET-1 were measured in a total of 1,410 patients presenting with cardiovascular risk factors (mean age 66.91±8.2 years, 49.3% males, mean left ventricular ejection fraction 60.0±8.2%) who had completed the Hospital Anxiety and Depression Scale (HADS) questionnaire.
Results: Among the total study cohort (n = 1,410), there were 118 subjects (8.4%) with an HADS anxiety score above the cut-off level of 11 suggestive of clinically relevant anxiety. Plasma CT-proET-1 levels were significantly lower in the group of anxious patients as compared to non-anxious patients (p = 0.013). In regression models adjusted for sex, age, systolic blood pressure, and diameters of left atrium and ventricle, plasma CT-proET-1 was again linked to anxiety (Exp(β) = 0.247, 95%-confidence interval [95%-CI] = 0.067-0.914, p = 0.036). Given the high prevalence of depressive disorders in anxious patients, we additionally included the HADS depression score as an independent variable in the models and found that CT-proET-1 remained a significant predictor of anxiety, independent of comorbid depression (Exp(β) = 0.114, 95%-CI = 0.023-0.566, p = 0.008).
Conclusions: Our data from a population-based study in outpatients with cardiovascular risk factors revealed that circulating CT-proET-1 levels are negatively associated with anxiety. Further investigations are required to clarify the putative anxiolytic effect of ET-1 or its precursor molecules in humans and to decipher its mechanistic pathways.
Databáze: MEDLINE
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