| Autor: |
Day TR; University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA. tyler.day@outlook.com., Smith DM; University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA.; Veterans Administration San Diego Healthcare System, San Diego, CA, USA., Heaton RK; Veterans Administration San Diego Healthcare System, San Diego, CA, USA., Franklin D; Veterans Administration San Diego Healthcare System, San Diego, CA, USA., Tilghman MW; Veterans Administration San Diego Healthcare System, San Diego, CA, USA., Letendre S; University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA., Jin H; University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA., Wu Z; Chinese Center for Disease Control and Prevention, Beijing, China., Shi C; Institute of Mental Health, Peking University, Beijing, China., Yu X; Institute of Mental Health, Peking University, Beijing, China., Pérez-Santiago J; University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093-0679, USA. |
| Abstrakt: |
Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese population. Individuals with HAND (global deficit score ≥0.5) had lower nadir (p < 0.01) and CD4(+) counts (p = 0.03). HAND was also associated with AIDS (p < 0.01), but subtype was not (p = 0.198). Furthermore, worse impairment correlated with higher viral diversity (r = 0.16, p < 0.01), lower nadir (r = -0.17, p < 0.01), and CD4(+) counts (r = -0.11, p = 0.01). These remained significant even when correcting for subtype. Our findings suggest that subtype does not have a major impact on HAND. |
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