[Nephrotic syndrome in Crohn's disease].
| Autor: | Boiten HJ; Albert Schweitzer Ziekenhuis, Dordrecht., Honkoop P, Smak Gregoor PJ |
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| Jazyk: | Dutch; Flemish |
| Zdroj: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2015; Vol. 159, pp. A9264. |
| Abstrakt: | Background: The differential diagnosis of nephrotic syndrome is diverse. Systemic conditions and medication such as NSAIDs can cause this syndrome. Case Description: A 33-year-old male with Crohn's disease for which he was receiving adalimumab noticed he was gaining weight and had swollen ankles. Examination revealed nephrotic syndrome without renal insufficiency. Renal biopsy showed a membranous glomerulopathy. We excluded secondary causes of membranous glomerulopathy such as diabetes mellitus, systemic lupus erythematosus, viral infection or malignancy. We treated the patient with high-dose glucocorticoids on a weaning schedule and adalimumab was discontinued. This regimen resulted in complete remission. It is likely that the nephrotic syndrome with membranous glomerulopathy was associated with adalimumab. Conclusion: In patients with nephrotic syndrome based on membranous glomerulopathy both primary and secondary causes, such as use of medication, need to be excluded. |
| Databáze: | MEDLINE |
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