| Autor: |
Sharpnack MF; The Ohio State University, Columbus, OH., Huang K; The Ohio State University, Columbus, OH. |
| Jazyk: |
angličtina |
| Zdroj: |
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science [AMIA Jt Summits Transl Sci Proc] 2015 Mar 23; Vol. 2015, pp. 41-5. Date of Electronic Publication: 2015 Mar 23 (Print Publication: 2015). |
| Abstrakt: |
Biological pathway regulation is complex, yet it underlies the functional coordination in a cell. Cancer is a disease that is characterized by unregulated growth, driven by underlying pathway deregulation. This pathway deregulation is both within pathways and between pathways. Here, we propose a method to detect inter-pathway coordination using distance correlation. Utilizing data generated from microarray experiments, we separate the genes into pathways and calculate the pairwise distance correlation between them. The result is intuitively viewed as a network of differentially dependent pathways. We find intuitive, yet surprising significant hub pathways, including glycophosphatidylinositol anchor synthesis in lung cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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