Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study.

Autor: Angelo HD; Department of General Formation, Federal Institute of Pernambuco, Garanhuns, Pernambuco, Brazil.; Postgraduate Program in Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Gomes Silva II; Postgraduate Program in Applied Molecular and Cellular Biology, University of Pernambuco (ICB/UPE), Recife, Pernambuco, Brazil., Oliveira RD; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Louzada-Júnior P; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Donadi EA; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Crovella S; Department of Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Maia MM; Department of Biology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil., de Souza PR; Department of Biology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil., Sandrin-Garcia P; Postgraduate Program in Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Jazyk: angličtina
Zdroj: Tissue antigens [Tissue Antigens] 2015 Oct; Vol. 86 (4), pp. 276-8. Date of Electronic Publication: 2015 Aug 25.
DOI: 10.1111/tan.12645
Abstrakt: Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77-fold increased risk of for RA (P = 0.0032). No association was observed for IL-12B and IFN-γ polymorphisms. Our finds suggest a possible role for IL-18 polymorphism in the RA susceptibility in studied population.
(© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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