Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.

Autor:	Harwell CC; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: corey_harwell@hms.harvard.edu., Fuentealba LC; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA., Gonzalez-Cerrillo A; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Parker PR; Gladstone Institute for Neurological Disease, San Francisco, CA 94158, USA., Gertz CC; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA., Mazzola E; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA., Garcia MT; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Alvarez-Buylla A; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA., Cepko CL; Departments of Genetics and Ophthalmology and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA., Kriegstein AR; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2015 Sep 02; Vol. 87 (5), pp. 999-1007. Date of Electronic Publication: 2015 Aug 20.
DOI:	10.1016/j.neuron.2015.07.030
Abstrakt:	The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed while unrelated interneurons can be closely clustered. These data suggest that migratory mechanisms related to the clustering of interneurons occur largely independent of their clonal origin. (Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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