The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.

Autor: Johnson A; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., Neumann PH; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., Peng J; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., James J; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., Russo V; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., MacDonald H; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., Gertzberg N; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States., Feleder C; Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, United States. Electronic address: carlos.feleder@acphs.edu.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2015 Sep 15; Vol. 286, pp. 16-24. Date of Electronic Publication: 2015 Jul 06.
DOI: 10.1016/j.jneuroim.2015.07.001
Abstrakt: We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lung weight)/(Ppc) ratio in the ICV-vehicle/LPS group at 4h. There were decreases in TLR4 pathway markers, such as interleukin receptor-associated kinase-1, IκBα, Raf1 and phospho-SFK (Tyr416) at 30min and at 4h increases in IL-6, vascular cell adhesion molecule-1 and myeloperoxidase in lung homogenate. Intracerebroventricular rimonabant attenuated these LPS-induced responses, indicating that ICV rimonabant modulates LPS-initiated pulmonary inflammation.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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