Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle Disease Virus outbreak in West Malaysia.

Autor: Jaganathan S; Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. seetha.jaganathan@rhonema.com.; Asia-Pacific Special Nutrients Sdn. Bhd, Lot 18B, Jalan 241, Section 51A, 46100, Petaling Jaya, Selangor, Malaysia. seetha.jaganathan@rhonema.com.; Vet Food Agro Diagnostic Sdn. Bhd., Lot 18B, Jalan 241, Section 51A, 46100, Petaling Jaya, Selangor, Malaysia. seetha.jaganathan@rhonema.com., Ooi PT; Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. ooi@upm.edu.my., Phang LY; Department of Biotechnology, Faculty of Biotechnology & Molecular Science, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia. phanglaiyee@upm.edu.my., Allaudin ZN; Department of Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. zeenathul@upm.edu.my., Yip LS; Rhone Ma Malaysia (M) Sdn Bhd, Lot 18B, Jalan 241, Section 51A, 46100, Petaling Jaya, Selangor, Malaysia. karen.yip@rhonema.com., Choo PY; Rhone Ma Malaysia (M) Sdn Bhd, Lot 18B, Jalan 241, Section 51A, 46100, Petaling Jaya, Selangor, Malaysia. raymond.choo@rhonema.com., Lim BK; Rhone Ma Malaysia (M) Sdn Bhd, Lot 18B, Jalan 241, Section 51A, 46100, Petaling Jaya, Selangor, Malaysia. bankeong.lim@rhonema.com., Lemiere S; Merial S.A.S., Bio R&D, 254, Rue Marcel Merieux, 69007, Lyon, France. stephane.lemiere@merial.com., Audonnet JC; Merial S.A.S., Bio R&D, 254, Rue Marcel Merieux, 69007, Lyon, France. jean-christophe.audonnet@merial.com.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2015 Aug 21; Vol. 11, pp. 219. Date of Electronic Publication: 2015 Aug 21.
DOI: 10.1186/s12917-015-0537-z
Abstrakt: Background: Newcastle disease virus remains a constant threat in commercial poultry farms despite intensive vaccination programs. Outbreaks attributed to ND can escalate and spread across farms and states contributing to major economic loss in poultry farms.
Results: Phylogenetic analysis in our study showed that eleven of the samples belonged to genotype VIId. All farms were concurrently positive with two immunosuppressive viruses; Infectious Bursal Disease Virus (IBDV) and Marek's Disease Virus (MDV). Amino acid sequence analysis confirmed that eleven of the samples had sequence motifs for velogenic/mesogenic strains; three were lentogenic.
Conclusion: In conclusion, no new NDV genotype was isolated from the 2011 NDV outbreak. This study suggests that the presence of other immunosuppressive agents such as IBD and MDV could have contributed to the dysfunction of the immune system of the chickens, causing severe NDV outbreaks in 2011. Risk factors related to biosecurity and farm practices appear to have a significant role in the severity of the disease observed in affected farms.
Databáze: MEDLINE
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