Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India.

Autor: Pramanik S; Kolkata Zonal Laboratory, CSIR-National Environmental Engineering Research Institute, i-8 Sector-C, East Kolkata Area Development Project, Kolkata 700107, India; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India. Electronic address: sr_pramanik@neeri.res.in., Surendran ST; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India., Arumugam S; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India., Devi S; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India., Krishnamurthi K; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India., Chakrabarti T; Environmental Health Division, CSIR-National Environmental Engineering Research Institute, Nehru Marg, Nagpur 440020, India.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2015 Sep; Vol. 40 (2), pp. 480-5. Date of Electronic Publication: 2015 Jul 29.
DOI: 10.1016/j.etap.2015.07.019
Abstrakt: Polymorphisms in DNA repair and multidrug resistance genes might contribute to interindividual and interethnic differences in DNA repair capacity and drug disposition respectively. In the present study, we determined the allele and genotype frequencies of four single nucleotide polymorphisms (SNPs) located in the DNA repair genes, XRCC1, XRCC3, XPD, OGG1, namely XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, and OGG1 Ser326Cys, respectively and two SNPs located in the multidrug resistance gene, ABCB1, namely ABCB1 C3435T and ABCB1 C1236T, in 33-35 healthy and unrelated Sindhi individuals, residing in the Vidarbha region of Central India and compared them with the Maharashtrian population from the same geographical region and some other HapMap populations from the HapMap database. The study findings reveal that the Indian Sindhis are closely related to the Maharashtrians as well as Utah residents with Northern and Western European ancestry and Gujarati Indians in Houston, Texas in the HapMap database.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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