Complete pathologic response as a prognostic factor for squamous cell carcinoma of the oropharynx post-chemoradiotherapy.

Autor:	Trufelli DC; Discipline of Oncology, Faculdade de Medicina do ABC, Santo André, SP, Brazil., Matos LL; Department of Public Health (Biostatistics), Faculdade de Medicina do ABC, Santo André, SP, Brazil. Electronic address: lmatos@amcham.com.br., Santana TA; Discipline of Oncology, Faculdade de Medicina do ABC, Santo André, SP, Brazil., Capelli Fde A; Discipline of Head and Neck Surgery, Faculdade de Medicina do ABC, Santo André, SP, Brazil., Kanda JL; Discipline of Head and Neck Surgery, Faculdade de Medicina do ABC, Santo André, SP, Brazil., Del Giglio A; Discipline of Oncology, Faculdade de Medicina do ABC, Santo André, SP, Brazil., Castro Junior Gd; Discipline of Oncology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2015 Sep-Oct; Vol. 81 (5), pp. 498-504. Date of Electronic Publication: 2015 Jul 21.
DOI:	10.1016/j.bjorl.2015.07.009
Abstrakt:	Introduction: Chemoradiotherapy for squamous cell carcinoma of the oropharynx (SCCO) provides good results for locoregional disease control, with high rates of complete clinical and pathologic responses, mainly in the neck. Objective: To determine whether complete pathologic response after chemoradiotherapy is related to the prognosis of patients with SCCO. Methods: Data were prospectively extracted from clinical records of N2 and N3 SCCO patients submitted to a planned neck dissection after chemoradiotherapy. Results: A total of 19 patients were evaluated. Half of patients obtained complete pathologic response in the neck. Distant or locoregional recurrence occurred in approximately 42% of patients, and 26% died. Statistical analysis showed an association between complete pathologic response and lower disease recurrence rate (77.8% vs. 20.8%; p=0.017) and greater overall survival (88.9% vs. 23.3%; p=0.049). Conclusion: The presence of a complete pathologic response after chemoradiotherapy positively influences the prognosis of patients with SCCO. (Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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