Electrostatic interaction effects on tension-induced pore formation in lipid membranes.

Autor:	Karal MA; Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan., Levadnyy V; Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.; Theoretical Problem Center of Physico-Chemical Pharmacology, Russian Academy of Sciences, Kоsugina, 4, Moscow 117977, Russia.; Nanomaterials Research Division, Research Institute of Electronics, Shizuoka University, Shizuoka 422-8529, Japan., Tsuboi TA; Department of Physics, Graduate School of Science, Shizuoka University, Shizuoka 422-8529, Japan., Belaya M; Theoretical Problem Center of Physico-Chemical Pharmacology, Russian Academy of Sciences, Kоsugina, 4, Moscow 117977, Russia., Yamazaki M; Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.; Nanomaterials Research Division, Research Institute of Electronics, Shizuoka University, Shizuoka 422-8529, Japan.; Department of Physics, Graduate School of Science, Shizuoka University, Shizuoka 422-8529, Japan.
Jazyk:	angličtina
Zdroj:	Physical review. E, Statistical, nonlinear, and soft matter physics [Phys Rev E Stat Nonlin Soft Matter Phys] 2015 Jul; Vol. 92 (1), pp. 012708. Date of Electronic Publication: 2015 Jul 06.
DOI:	10.1103/PhysRevE.92.012708
Abstrakt:	We investigated the effects of electrostatic interactions on the rate constant (k(p)) for tension-induced pore formation in lipid membranes of giant unilamellar vesicles under constant applied tension. A decrease in salt concentration in solution as well as an increase in surface charge density of the membranes increased k(p). These data indicate that k(p) increases as the extent of electrostatic interaction increases. We developed a theory on the effect of the electrostatic interactions on the free energy profile of the membrane containing a prepore and also on the values of k(p); this theory explains the experimental results and fits the experimental data reasonably well in the presence of weak electrostatic interactions. Based on these results, we conclude that a decrease in the free energy barrier of the prepore state due to electrostatic interactions is the main factor causing an increase in k(p).
Databáze:	MEDLINE
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