Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS).

Autor: Storch A; Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Alexander.Storch@med.uni-rostock.de.; German Center for Neurodegenerative Diseases (DZNE) Dresden, 01307, Dresden, Germany. Alexander.Storch@med.uni-rostock.de.; Department of Neurology, University of Rostock, 18147, Rostock, Germany. Alexander.Storch@med.uni-rostock.de., Schneider CB; Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany., Klingelhöfer L; Division of Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany., Odin P; Department of Neurology, Klinikum Bremerhaven, 27574, Bremerhaven, Germany.; Department of Neurology, Skane University Hospital, 221 85, Lund, Sweden., Fuchs G; Parkinson Clinic Wolfach, 77709, Wolfach, Germany., Jost WH; Department of Neurology, Deutsche Klinik für Diagnostik, 65191, Wiesbaden, Germany., Martinez-Martin P; Research Unit, Alzheimer Center Reina Sofia Foundation and CIBERNED, Carlos III Institute of Health, 28031, Madrid, Spain., Koch R; Department of Medical Informatics and Biometry, Technische Universität Dresden, 01307, Dresden, Germany., Reichmann H; Department of Neurology, Technische Universität Dresden, 01307, Dresden, Germany., Chaudhuri KR; National Parkinson Foundation Centre of Excellence, Kings College Hospital and Kings College London and Biomedical Research Centre, Kings College London, London, UK., Ebersbach G; Movement Disorders Clinic, 14547, Beelitz-Heilstätten, Germany.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2015 Dec; Vol. 122 (12), pp. 1673-84. Date of Electronic Publication: 2015 Aug 12.
DOI: 10.1007/s00702-015-1437-x
Abstrakt: Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. ΔNMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 ± 9.7 years) with mean total NMSS score in On state of 41.5 ± 37.6 and in Off state of 75.6 ± 42.3 (P < 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and ΔNMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression.
Databáze: MEDLINE
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