Genetic Alterations in Hungarian Patients with Papillary Thyroid Cancer.

Autor: Tobiás B; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary. tobias.balint@med.semmelweis-univ.hu., Halászlaki C; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Balla B; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Kósa JP; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.; PentaCore Laboratory, Budapest, Hungary., Árvai K; PentaCore Laboratory, Budapest, Hungary., Horváth P; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Takács I; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Nagy Z; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Horváth E; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Horányi J; 1st Department of Surgery, Semmelweis University, Budapest, Hungary., Járay B; 2nd Department of Pathology, Semmelweis University, Budapest, Hungary., Székely E; 2nd Department of Pathology, Semmelweis University, Budapest, Hungary., Székely T; 2nd Department of Pathology, Semmelweis University, Budapest, Hungary., Győri G; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary., Putz Z; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Dank M; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary., Valkusz Z; Department of Medicine, University of Szeged, Szeged, Hungary., Vasas B; Department of Pathology, University of Szeged, Szeged, Hungary., Iványi B; Department of Pathology, University of Szeged, Szeged, Hungary., Lakatos P; 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.
Jazyk: angličtina
Zdroj: Pathology oncology research : POR [Pathol Oncol Res] 2016 Jan; Vol. 22 (1), pp. 27-33. Date of Electronic Publication: 2015 Aug 11.
DOI: 10.1007/s12253-015-9969-9
Abstrakt: The incidence of thyroid cancers is increasing worldwide. Some somatic oncogene mutations (BRAF, NRAS, HRAS, KRAS) as well as gene translocations (RET/PTC, PAX8/PPAR-gamma) have been associated with the development of thyroid cancer. In our study, we analyzed these genetic alterations in 394 thyroid tissue samples (197 papillary carcinomas and 197 healthy). The somatic mutations and translocations were detected by Light Cycler melting method and Real-Time Polymerase Chain Reaction techniques, respectively. In tumorous samples, 86 BRAF (44.2%), 5 NRAS (3.1%), 2 HRAS (1.0%) and 1 KRAS (0.5%) mutations were found, as well as 9 RET/PTC1 (4.6%) and 1 RET/PTC3 (0.5%) translocations. No genetic alteration was seen in the non tumorous control thyroid tissues. No correlation was detected between the genetic variants and the pathological subtypes of papillary cancer as well as the severity of the disease. Our results are only partly concordant with the data found in the literature.
Databáze: MEDLINE
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