A Method for Psychosocial Stress-Induced Reinstatement of Cocaine Seeking in Rats.

Autor: Manvich DF; Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia., Stowe TA; Neuroscience and Behavioral Biology Program, Emory University, Atlanta, Georgia., Godfrey JR; Division of Neuropharmacology and Neurologic Diseases and Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia., Weinshenker D; Department of Human Genetics, Emory University School of Medicine, Emory University, Atlanta, Georgia. Electronic address: dweinshenker@genetics.emory.edu.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2016 Jun 01; Vol. 79 (11), pp. 940-6. Date of Electronic Publication: 2015 Jul 08.
DOI: 10.1016/j.biopsych.2015.07.002
Abstrakt: We describe a novel preclinical model of stress-induced relapse to cocaine use in rats using social defeat stress, an ethologically valid psychosocial stressor in rodents that closely resembles stressors that promote craving and relapse in humans. Rats self-administered cocaine for 20 days. On days 11, 14, 17, and 20, animals were subjected to social defeat stress or a nonstressful control condition following the session, with discrete environmental stimuli signaling the impending event. After extinction training, reinstatement was assessed following re-exposure to these discrete cues. Animals re-exposed to psychosocial stress-predictive cues exhibited increased serum corticosterone and significantly greater reinstatement of cocaine seeking than the control group, and active coping behaviors during social defeat episodes were associated with subsequent reinstatement magnitude. These studies are the first to describe an operant model of psychosocial stress-induced relapse in rodents and lay the foundation for future work investigating its neurobiological underpinnings.
(Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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