dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.

Autor:	Nelson AM; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Reddy SK; Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Ratliff TS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Hossain MZ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Katseff AS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Zhu AS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Chang E; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Resnik SR; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Page C; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Kim D; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Whittam AJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Garza LA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address: lag@jhmi.edu.
Jazyk:	angličtina
Zdroj:	Cell stem cell [Cell Stem Cell] 2015 Aug 06; Vol. 17 (2), pp. 139-51.
DOI:	10.1016/j.stem.2015.07.008
Abstrakt:	Regeneration of skin and hair follicles after wounding--a process known as wound-induced hair neogenesis (WIHN)--is a rare example of adult organogenesis in mammals. As such, WIHN provides a unique model system for deciphering mechanisms underlying mammalian regeneration. Here, we show that dsRNA, which is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors IL-6 and STAT3 to promote hair follicle regeneration. Conversely, TLR3-deficient animals fail to initiate WIHN. TLR3 activation promotes expression of hair follicle stem cell markers and induces elements of the core hair morphogenetic program, including ectodysplasin A receptor (EDAR) and the Wnt and Shh pathways. Our results therefore show that dsRNA and TLR3 link the earliest events of mammalian skin wounding to regeneration and suggest potential therapeutic approaches for promoting hair neogenesis. (Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu