Small Molecules Take a Big Step by Converting Fibroblasts into Neurons.

Autor:	Babos K; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90033, USA., Ichida JK; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: ichida@usc.edu.
Jazyk:	angličtina
Zdroj:	Cell stem cell [Cell Stem Cell] 2015 Aug 06; Vol. 17 (2), pp. 127-9.
DOI:	10.1016/j.stem.2015.07.018
Abstrakt:	Direct lineage conversion could provide a rich source of somatic cell types for translational medicine, but concerns over the use of transgenic reprogramming factors have limited its potential. In this issue of Cell Stem Cell, Li et al. (2015) and Hu et al. (2015) identify small-molecule cocktails that can convert fibroblasts into functional neurons without exogenous genetic factors. (Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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