Prevalence of hepatitis B markers in Senegalese HIV-1-infected patients.

Autor: Lô G; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Sow-Sall A; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Diop-Ndiaye H; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Mandiouba NC; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Thiam M; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Diop F; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Ndiaye O; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Gueye SB; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Seck SM; University of Gaston Berger of Saint Louis, Saint Louis, Senegal., Dioura AA; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Mbow M; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Gaye-Diallo A; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Mboup S; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal., Touré-Kâne C; Bacteriology and Virology Laboratory at Le Dantec Teaching Hospital of Dakar, Dakar, Senegal.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2016 Mar; Vol. 88 (3), pp. 461-5. Date of Electronic Publication: 2015 Aug 20.
DOI: 10.1002/jmv.24344
Abstrakt: The study aimed to estimate the prevalence of Hepatitis B virus (HBV) infection and to describe the HBV virological profiles among Senegalese HIV-1-infected patients. We conducted a retrospective study between 2006 and 2010 among Senegalese HIV-1-infected patients from the antiretroviral therapy cohort. Samples were screened using Determine(®) HBsAg or MONOLISA(®) POC test. The HBsAg positivity status was confirmed by Architect(®) HBsAg. Detection of HBeAg, anti-HBe Ab, and HBV DNA load were done for the HBsAg-positive samples. Then, Anti-HBcAb was tested for the HBsAg-negative samples. Microsoft Excel was used for data collection and statistical analyses were performed using Epi info 3.5.1. Overall, 466 HIV-infected patients were enrolled including 271 women (58.4%), and 193 men (41.6%) with a median age of 39 years (19-74 years). The global prevalence of HIV/HBV coinfection (HBsAg positive) was 8.8% (41/466). For HBsAg positives samples, the prevalence of HBeAg and the anti-HBeAb were, respectively, 24.4 and 69.2% and the median of HBV DNA viral load, for 27 HBsAg-positive samples, was 3.75 log10 copies/ml. The virological profiles were the following: 7, 15, and 5 patients infected, respectively, by a replicative virus, an inactive virus and a probably mutant virus. For HBsAg-negative samples, 83 out of 109 were positive for anti-HBcAb. This study showed a significant decrease of the prevalence of HBV/HIV coinfection between 2004 and 2014 (P = 0.003), which highlighted the performance of the Senegalese HBV vaccine program. However, implementing a systematic quantification of HBV DNA viral load could improve the monitoring of HBV-infected patient.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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