Continuous microwave flow synthesis of mesoporous hydroxyapatite.

Autor: Akram M; Department of Chemistry, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia., Alshemary AZ; Department of Chemistry, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia., Goh YF; Department of Chemistry, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia., Wan Ibrahim WA; Department of Chemistry, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia., Lintang HO; Centre for Sustainable Nanomaterials (CSNano), Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia., Hussain R; Centre for Sustainable Nanomaterials (CSNano), Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia. Electronic address: rafaqat@kimia.fs.utm.my.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2015 Nov 01; Vol. 56, pp. 356-62. Date of Electronic Publication: 2015 Jun 24.
DOI: 10.1016/j.msec.2015.06.040
Abstrakt: We have successfully used continuous microwave flow synthesis (CMFS) technique for the template free synthesis of mesoporous hydroxyapatite. The continuous microwave flow reactor consisted of a modified 2.45GHz household microwave, peristaltic pumps and a Teflon coil. This cost effective and efficient system was exploited to produce semi-crystalline phase pure nano-sized hydroxyapatite. Effect of microwave power, retention time and the concentration of reactants on the phase purity, degree of crystallinity and surface area of the final product was studied in detail. X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to study the phase purity and composition of the product, while transmission electron microscopy (TEM) was used to study the effect of process parameters on the morphology of hydroxyapatite. The TEM analysis confirmed the formation of spherical particles at low microwave power; however the morphology of the particles changed to mesoporous needle and rod-like structure upon exposing the reaction mixture to higher microwave power and longer retention time inside the microwave. The in-vitro ion dissolution behavior of the as synthesized hydroxyapatite was studied by determining the amount of Ca(2+) ion released in SBF solution.
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Databáze: MEDLINE