A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou, China.

Autor:	Xu LF; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Zhou XL; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Wang Q; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Zhou JL; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Liu YP; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Ju Q; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Wang H; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Zhang JP; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Wu QR; Obstetrical Department, Maternal and Child Health Hospital of Xuzhou City, Xuzhou 221009, Jiangsu, China., Li YQ; Obstetrical Department, Maternal and Child Health Hospital of Xuzhou City, Xuzhou 221009, Jiangsu, China., Xia YJ; Obstetrical Department, Maternal and Child Health Hospital of Xuzhou City, Xuzhou 221009, Jiangsu, China., Peng X; Obstetrical Department, Maternal and Child Health Hospital of Xuzhou City, Xuzhou 221009, Jiangsu, China., Zhang MR; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Yu HM; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China., Xu LC; School of Public Health, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China.
Jazyk:	angličtina
Zdroj:	Biomedical and environmental sciences : BES [Biomed Environ Sci] 2015 Jul; Vol. 28 (7), pp. 535-8.
DOI:	10.3967/bes2015.076
Abstrakt:	In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City. We conducted face-to-face interviews with the mothers of both cases and controls. The factors increasing the risk of NSCLP were a positive family history [odds ratio (OR)=56.74], pesticide exposure (OR=8.90), and indoor decoration pollution (OR=4.32). On the other hand, the factors decreasing the risk of NSCLP were a high education level (OR=0.22) and supplementation of folic acid (OR=0.23) and multivitamins (OR=0.16). Positive family history, pesticide exposure, and indoor decoration pollution are associated with the risk of NSCLP. In contrast, high education level and folic acid and multivitamin supplementation are protective factors against NSCLP. (Copyright © 2015 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)
Databáze:	MEDLINE
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