Effect of circadian variability in frequency of premature ventricular complexes on left ventricular function.

Autor:	Bas HD; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan., Baser K; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan., Hoyt J; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan., Yokokawa M; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan., LaBounty T; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan., Morady F; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan., Bogun F; Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan. Electronic address: fbogun@med.umich.edu.
Jazyk:	angličtina
Zdroj:	Heart rhythm [Heart Rhythm] 2016 Jan; Vol. 13 (1), pp. 98-102. Date of Electronic Publication: 2015 Aug 03.
DOI:	10.1016/j.hrthm.2015.07.038
Abstrakt:	Background: Frequent idiopathic premature ventricular complexes (PVCs) can result in a reversible form of cardiomyopathy. Objective: The purpose of this study was to assess the impact of variability in PVC frequency throughout the day on PVC-induced cardiomyopathy. Methods: The subjects of this study were 107 consecutive patients (58 men [54%]; mean age 49.7 ± 15.0 years; left ventricular ejection fraction 50.4% ± 11.4%) referred for ablation of frequent PVCs. All patients underwent 24-hour Holter monitoring before the ablation procedure. The circadian variation in PVC burden was determined and correlated with the presence or absence of cardiomyopathy. Results: A total of 43 patients (40%) had cardiomyopathy. Patients with cardiomyopathy had an ejection fraction of 38.4% ± 6.9%, a higher PVC burden (28.5% ± 11.5% vs 19.5% ± 10.5%; P = .0001), less variability in circadian PVC distribution (coefficient of variation hourly: 31.5% ± 21% vs 59.8% ± 32.4%; P = .0001), and more frequent interpolated PVCs (20 patients [47%] vs 15 patients [23%]; P = 0.022), and were more frequently asymptomatic than patients without cardiomyopathy (56% vs 19%; P = .0001). In multivariate analysis, consistency in PVC burden throughout the day was an independent predictor of PVC-induced cardiomyopathy (odds ratio 16.3; 95% confidence interval 1.7-155.3; p = 0.015). Conclusion: In patients with frequent PVCs, consistency in hourly PVC frequency throughout the day is an independent predictor of PVC-induced cardiomyopathy. (Copyright © 2016 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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