HIV Associated Chronic Obstructive Pulmonary Disease in Nigeria.

Autor: Akanbi MO; Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria., Taiwo BO; Northwestern University Chicago, USA., Achenbach CJ; Northwestern University Chicago, USA., Ozoh OB; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Obaseki DO; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria., Sule H; Department of Family Medicine, Jos University Teaching Hospital, Nigeria., Agbaji OO; Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria., Ukoli CO; Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria.
Jazyk: angličtina
Zdroj: Journal of AIDS & clinical research [J AIDS Clin Res] 2015 May; Vol. 6 (5).
DOI: 10.4172/2155-6113.1000453
Abstrakt: Objective: To determine the prevalence and risk factors for chronic obstructive pulmonary disease (COPD) among HIV-infected adults in Nigeria.
Design: Cross-sectional study.
Methods: HIV-infected adults aged ≥ 30 years with no acute ailments accessing care at the antiretroviral therapy clinic of Jos University Teaching Hospital were enrolled consecutively. Participants were interviewed to obtain pertinent demographic and clinical information, including exposure to risk factors for COPD. Post-bronchodilator spirometry was carried out. HIV related information was retrieved from the clinic medical records. COPD case-definition was based on the Global Initiative for Obstructive Lung Disease (GOLD) criteria using post-bronchodilator FEV 1 /FVC <0.7. COPD prevalence was also calculated using the lower limit of normal for FEV 1 /FVC criteria (LLN) from the European Respiratory Society normative equation. Factors associated with COPD were determined using logistic regression models.
Results: Study population comprised 356 HIV infected adults with mean age of 44.5 (standard deviation, 7.1) years and 59% were female. The mean time elapsed since HIV diagnosis was 7.0 (SD, 2.6) years and 97.5% of the respondents were on stable ART with virologic suppression present in 67.2%. Prevalence of COPD were 15.4% (95% confidence interval [CI] 11.7-19.2), 12.07% (95% CI 8.67-15.48), 22.19% (95% CI 18.16-26.83) using GOLD, ERS LLN and GLI LLN diagnostic criteria respectively. In multivariate analyses adjusting for gender, exposure to cigarette smoke or biomass, history of pulmonary tuberculosis, use of antiretroviral therapy, current CD4 T-cell count and HIV RNA, only age > 50 years was independently associated with COPD with OR 3.4; 95% CI 1.42-8.17 when compared to ages 30-40 years.
Conclusion: HIV-associated COPD is common in our population of HIV patients.
Databáze: MEDLINE
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