| Autor: |
Santhosh Kumar G; Fluoroorganic Division, Indian Institute of Chemical Technology., Jitender Dev G, Ravi Kumar N, Krishna Swaroop D, Poorna Chandra Y, Ganesh Kumar C, Narsaiah B |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2015; Vol. 63 (8), pp. 584-90. |
| DOI: |
10.1248/cpb.c15-00219 |
| Abstrakt: |
A series of novel pyrido[1,2-a]pyrimidine-3-carboxamide derivatives 6a-n were prepared starting from 2(1H) pyridone 1 via hydrolysis, de-carboxylation, selective O-alkylation followed by rearrangement to give pyridine-2-amine 3. Compound 3 on reaction with ethoxy methylene malonic diethyl ester (EMME) under a conventional method followed by cyclization under micro wave irradiation (MWI) conditions resulted in product 5. Compound 5 on coupling with diverse substituted aliphatic amines formed title compounds 6a-n. All the products 6a-n were screened against four human cancer cell lines and compounds 6h-k and n which showed promising anticancer activity have been identified. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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