Activation of presynaptic oxytocin receptors enhances glutamate release in the ventral hippocampus of prenatally restraint stressed rats.

Autor: Mairesse J; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Gatta E; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Reynaert ML; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Marrocco J; Laboratory of Neuroendocrinology, The Rockefeller University, 10065 New York, NY, USA; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Morley-Fletcher S; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Soichot M; Faculté de Médecine de Lille, UDSL, 59045 Lille, France., Deruyter L; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Camp GV; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Bouwalerh H; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Fagioli F; Azienda Sanitaria Locale, RM.E. Unità Operativa Complessa Adolescent, 00100 Rome, Italy., Pittaluga A; Dept of Pharmacy, Univ. of Genoa, 16126 Genoa, Italy., Allorge D; Faculté de Médecine de Lille, UDSL, 59045 Lille, France., Nicoletti F; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; IRCCS Neuromed, 86077 Pozzilli, Italy; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy., Maccari S; Univ.Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; LIA France/Italy (International Associated Laboratory 'Prenatal Stress and Neurodegenerative Diseases', Glycobiology of Stress-related Diseases team, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France; Neuromed, 86077-Pozzilli, Italy and Sapienza University of Rome, 00185-Rome, Italy. Electronic address: stefania.maccari@univ-lille1.fr.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2015 Dec; Vol. 62, pp. 36-46. Date of Electronic Publication: 2015 Jul 18.
DOI: 10.1016/j.psyneuen.2015.07.005
Abstrakt: Oxytocin receptors are known to modulate synaptic transmission and network activity in the hippocampus, but their precise function has been only partially elucidated. Here, we have found that activation of presynaptic oxytocin receptor with the potent agonist, carbetocin, enhanced depolarization-evoked glutamate release in the ventral hippocampus with no effect on GABA release. This evidence paved the way for examining the effect of carbetocin treatment in "prenatally restraint stressed" (PRS) rats, i.e., the offspring of dams exposed to repeated episodes of restraint stress during pregnancy. Adult PRS rats exhibit an anxious/depressive-like phenotype associated with an abnormal glucocorticoid feedback regulation of the hypothalamus-pituitary-adrenal (HPA) axis, and, remarkably, with a reduced depolarization-evoked glutamate release in the ventral hippocampus. Chronic systemic treatment with carbetocin (1mg/kg, i.p., once a day for 2-3 weeks) in PRS rats corrected the defect in glutamate release, anxiety- and depressive-like behavior, and abnormalities in social behavior, in the HPA response to stress, and in the expression of stress-related genes in the hippocampus and amygdala. Of note, carbetocin treatment had no effect on these behavioral and neuroendocrine parameters in prenatally unstressed (control) rats, with the exception of a reduced expression of the oxytocin receptor gene in the amygdala. These findings disclose a novel function of oxytocin receptors in the hippocampus, and encourage the use of oxytocin receptor agonists in the treatment of stress-related psychiatric disorders in adult life.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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