Ischaemic heart disease incidence and mortality in an extended cohort of Mayak workers first employed in 1948-1982.

Autor:	Azizova TV; 1 Clinical Department, Southern Urals Biophysics Institute, Ozyorsk, Russia., Grigoryeva ES; 1 Clinical Department, Southern Urals Biophysics Institute, Ozyorsk, Russia., Haylock RG; 2 Epidemiology Department, Public Health England, Didcot, UK., Pikulina MV; 1 Clinical Department, Southern Urals Biophysics Institute, Ozyorsk, Russia., Moseeva MB; 1 Clinical Department, Southern Urals Biophysics Institute, Ozyorsk, Russia.
Jazyk:	angličtina
Zdroj:	The British journal of radiology [Br J Radiol] 2015 Oct; Vol. 88 (1054), pp. 20150169. Date of Electronic Publication: 2015 Jul 30.
DOI:	10.1259/bjr.20150169
Abstrakt:	Objective: Incidence and mortality from ischaemic heart disease (IHD) was studied in an extended cohort of 22,377 workers first employed at the Mayak Production Association during 1948-82 and followed up to the end of 2008. Methods: Relative risks and excess relative risks per unit dose (ERR/Gy) were calculated based on the maximum likelihood using Epicure software (Hirosoft International Corporation, Seattle, WA). Dose estimates used in analyses were provided by an updated "Mayak Worker Dosimetry System-2008". Results: A significant increasing linear trend in IHD incidence with total dose from external γ-rays was observed after having adjusted for non-radiation factors and dose from internal radiation {ERR/Gy = 0.10 [95% confidence interval (CI): 0.04 to 0.17]}. The pure quadratic model provided a better fit of the data than did the linear one. No significant association of IHD mortality with total dose from external γ-rays after having adjusted for non-radiation factors and dose from internal alpha radiation was observed in the study cohort [ERR/Gy = 0.06 (95% CI: <0 to 0.15)]. A significant increasing linear trend was observed in IHD mortality with total absorbed dose from internal alpha radiation to the liver after having adjusted for non-radiation factors and dose from external γ-rays in both the whole cohort [ERR/Gy = 0.21 (95% CI: 0.01 to 0.58)] and the subcohort of workers exposed at alpha dose <1.00 Gy [ERR/Gy = 1.08 (95% CI: 0.34 to 2.15)]. No association of IHD incidence with total dose from internal alpha radiation to the liver was found in the whole cohort after having adjusted for non-radiation factors and external gamma dose [ERR/Gy = 0.02 (95% CI: not available to 0.10)]. Statistically significant dose effect was revealed in the subcohort of workers exposed to internal alpha radiation at dose to the liver <1.00 Gy [ERR/Gy = 0.44 (95% CI: 0.09 to 0.85)]. Conclusion: This study provides strong evidence of IHD incidence and mortality association with external γ-ray exposure and some evidence of IHD incidence and mortality association with internal alpha-radiation exposure. Advances in Knowledge: It is the first time the validity of internal radiation dose estimates has been shown to affect the risk of IHD incidence.
Databáze:	MEDLINE
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