| Autor: |
Nouga AB; a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon., Ndom JC; a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon., Mpondo EM; b Department of Pharmacy , University of Douala , Douala P.O. Box 2701 , Cameroon., Nyobe JC; b Department of Pharmacy , University of Douala , Douala P.O. Box 2701 , Cameroon., Njoya A; a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon., Meva'a LM; a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon., Cranwell PB; c Department of Chemistry , University of Reading , Whitenights, Reading RG6 6AD , UK., Howell JA; d Lennard Jones Laboratory, Department of Chemistry, School of Physical and Geographical Sciences , University of Keele , Staffordshire ST5 5BG , UK., Harwood LM; c Department of Chemistry , University of Reading , Whitenights, Reading RG6 6AD , UK., Wansi JD; a Department of Chemistry , University of Douala , Douala P.O. Box 24157 , Cameroon. |
| Abstrakt: |
Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxy-dictamnine (1) and a flavanone glycoside named 5-hydroxy-4'-methoxy-7-O-[α-L-rhamnopyranosyl(1‴→5″)-β-D-apiofuranosyl]-flavanoside (2), together with 11 known compounds (3-13). The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines. The alkaloids 1, 5, 12, 13 and the phenolic 2, 8, 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC50 8.7-15.9 μM whereas compounds 3, 4, 6, 7, 9 and 10 showed low activity. |
