KCa1.1 is potential marker for distinguishing Ah-type baroreceptor neurons in NTS and contributes to sex-specific presynaptic neurotransmission in baroreflex afferent pathway.

Autor: Zhang YY; Department of Anatomy, Histology, and Embryology, Heilongjiang University of Chinese Medicine, Harbin, China; Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, China., Yan ZY; Department of Pharmacology, Harbin Medical University, Harbin, China., Qu MY; Department of Pharmacology, Harbin Medical University, Harbin, China., Guo XJ; Department of Pharmacology, Harbin Medical University, Harbin, China., Li G; Department of Pharmacology, Harbin Medical University, Harbin, China., Lu XL; Department of Pharmacology, Harbin Medical University, Harbin, China., Liu Y; Department of Pharmacology, Harbin Medical University, Harbin, China., Ban T; Department of Pharmacology, Harbin Medical University, Harbin, China; Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, China., Sun HL; Department of Pharmacology, Da-Qing Campus of Harbin Medical University, Da-Qing, China., Qiao GF; Department of Pharmacology, Harbin Medical University, Harbin, China; Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin Medical University, China. Electronic address: qiaogf88@163.com., Li BY; Department of Pharmacology, Harbin Medical University, Harbin, China. Electronic address: liby@ems.hrbmu.edu.cn.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2015 Sep 14; Vol. 604, pp. 1-6. Date of Electronic Publication: 2015 Jul 26.
DOI: 10.1016/j.neulet.2015.07.023
Abstrakt: Sexual-dimorphic neurocontrol of circulation has been described in baroreflex due largely to the function of myelinated Ah-type baroreceptor neurons (BRNs, 1st-order) in nodose. However, it remains unclear if sex- and afferent-specific neurotransmission could also be observed in the central synapses within nucleus of solitary track (NTS, 2nd-order). According to the principle of no mixed neurotransmission among afferents and differentiation of Ah- and A-types to iberiotoxin (IbTX) observed in nodose, the 2nd-order Ah-type BRNs are highly expected. To test this hypothesis, the excitatory post-synaptic currents (EPSCs) were recorded in identified 2nd-order BRNs before and after IbTX using brain slice and whole-cell patch. These results showed that, in male rats, the dynamics of EPSCs in capsaicin-sensitive C-types were dramatically altered by IbTX, but not in capsaicin-insensitive A-types. Interestingly, near 50% capsaicin-insensitive neurons in females showed similar effects to C-types, suggesting the existence of Ah-types in NTS, which may be the likely reason why the females had lower blood pressure and higher sensitivity to aortic depressor nerve stimulation via KCa1.1-mediated presynaptic glutamate release from Ah-type afferent terminals.
(Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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