Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas.

Autor: Pinkney KA; Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplantation, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. kpinkney@mhs.net.; Current address: Joe DiMaggio's Children's Hospital, 1150 North 35th Avenue, Suite 100, Hollywood, FL, 33021, USA. kpinkney@mhs.net., Jiang W; Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave, RM 503B, New York, NY, 10032, USA. jw759@columbia.edu.; Herbert Irving Comprehensive Cancer Research Center, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. jw759@columbia.edu., Lee BJ; Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave, RM 503B, New York, NY, 10032, USA. bl2530@columbia.edu., Loredan DG; Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave, RM 503B, New York, NY, 10032, USA. dl2970@columbia.edu., Li C; Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave, RM 503B, New York, NY, 10032, USA. cl3103@columbia.edu., Bhagat G; Herbert Irving Comprehensive Cancer Research Center, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. gb96@columbia.edu.; Department of Pathology and Cell Biology, College for Physicians and Surgeons, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. gb96@columbia.edu., Zha S; Institute for Cancer Genetics, Columbia University, 1130 St Nicholas Ave, RM 503B, New York, NY, 10032, USA. sz2296@columbia.edu.; Herbert Irving Comprehensive Cancer Research Center, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. sz2296@columbia.edu.; Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplantation, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. sz2296@columbia.edu.; Department of Pathology and Cell Biology, College for Physicians and Surgeons, Columbia University, 1130 St Nicholas Ave, New York, NY, 10032, USA. sz2296@columbia.edu.
Jazyk: angličtina
Zdroj: Journal of hematology & oncology [J Hematol Oncol] 2015 Jul 30; Vol. 8, pp. 94. Date of Electronic Publication: 2015 Jul 30.
DOI: 10.1186/s13045-015-0191-8
Abstrakt: Bcl11b is a transcription factor important for T cell development and also a tumor-suppressor gene that is hemizygously inactivated in ~10% human T cell acute lymphoblastic leukemia (T-ALL) and several murine T-ALL models, including ATM(-/-) thymic lymphomas. Here we report that heterozygous loss of Bcl11b (Bcl11b(+/-)) unexpectedly reduced lethal thymic lymphoma in ATM(-/-) mice by suppressing lymphoma progression, but not initiation. The suppression was associated with a T cell-mediated immune response in ATM(-/-)Bcl11b(+/-) mice, revealing a haploid insufficient function of Bcl11b in immune modulation against lymphoma and offering an explanation for the complex relationship between Bcl11b status with T-ALL prognosis.
Databáze: MEDLINE
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