Beneficial effect of Omega-3 polyunsaturated fatty acids on neurosensorial impairments and oxidative status in Streptozotocin induced diabetic rats.
| Autor: | Yadav S, Mitha KV, Shenoy MT, Mayannavar S, Ganaraja B |
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| Jazyk: | angličtina |
| Zdroj: | Indian journal of physiology and pharmacology [Indian J Physiol Pharmacol] 2014 Oct-Dec; Vol. 58 (4), pp. 346-53. |
| Abstrakt: | Objectives: The present study evaluated the beneficial effects of omega 3 PUFA present in fish oil on neurosensorial impairments, namely learning, memory and anxiety in Streptozotocin (STZ) induced diabetic rats. The brain homogenate was analysed for oxidative status following Omega 3 PUFA treatment. Methods: Male, Wistar rats of 2-3 months old were divided into non diabetic controls, diabetic control, & fish oil treated diabetic rats (n = 6). Diabetes was induced by injection of STZ (48 mg/kg, ip). Animals were treated orally for 30 days with a dose in each group of 0.5 g/kg/day of fish oil. All experiments were conducted after ethical committee clearance was obtained. Results: Memory and exploratory behavior were improved (p < 0.01) in fish oil treated rats as compared with diabetic rats. A significant (p < 0.001) decrease in MDA and a significant increase (p < 0.001) in total antioxidant level (TAO) were observed in fish oil treated rats. Conclusion: Omega 3 PUFA present in fish oil could be used an adjuvant therapy for treatment and prevention of neurosensorial impairment in diabetes mellitus. |
| Databáze: | MEDLINE |
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