Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.

Autor:	Kar SP; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. sk718@medschl.cam.ac.uk., Tyrer JP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Li Q; Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Lawrenson K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Aben KK; Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands. Comprehensive Cancer Center The Netherlands, Utrecht, the Netherlands., Anton-Culver H; Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California., Antonenkova N; Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus., Chenevix-Trench G; Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Baker H; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Bandera EV; Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey., Bean YT; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Beckmann MW; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Berchuck A; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina., Bisogna M; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Bjørge L; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Bogdanova N; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Brinton L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Brooks-Wilson A; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada., Butzow R; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland. Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland., Campbell I; Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Department of Pathology, University of Melbourne, Parkville, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Carty K; Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Chang-Claude J; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Chen YA; Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida., Chen Z; Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida., Cook LS; Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico., Cramer D; Obstetrics and Gynecology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Harvard School of Public Health, Boston, Massachusetts., Cunningham JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Cybulski C; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Dansonka-Mieszkowska A; Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Dicks E; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Doherty JA; Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., du Bois A; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Dürst M; Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany., Eccles D; Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Edwards RP; Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom. Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania., Ekici AB; University Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Fasching PA; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany. University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, Los Angeles, California., Fridley BL; Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas., Gao YT; Shanghai Cancer Institute, Shanghai, China., Gentry-Maharaj A; Women's Cancer, University College London Elizabeth Garrett Anderson Institute for Women's Health, London, United Kingdom., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia., Glasspool R; Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Goode EL; Department of Health Science Research, Mayo Clinic, Rochester, Minnesota., Goodman MT; Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California., Grownwald J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Harrington P; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Harter P; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Hein A; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Heitz F; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Hildebrandt MA; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hillemanns P; Departments of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany., Hogdall E; Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark., Hogdall CK; Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Hosono S; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan., Iversen ES; Department of Statistical Science, Duke University, Durham, North Carolina., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Paul J; Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Jensen A; Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark., Ji BT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Karlan BY; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Kjaer SK; Virus, Lifestyle, and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Kelemen LE; Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina., Kellar M; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Kelley J; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Kiemeney LA; Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands., Krakstad C; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Kupryjanczyk J; Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Lambrechts D; Vesalius Research Center, VIB, Leuven, Belgium. Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium., Lambrechts S; Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium., Le ND; Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada., Lee AW; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Lele S; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York., Leminen A; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland., Lester J; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Levine DA; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York., Liang D; College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas., Lissowska J; Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Lu K; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lubinski J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lundvall L; Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Massuger L; Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Matsuo K; Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan., McGuire V; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California., McLaughlin JR; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., McNeish IA; Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, United Kingdom., Menon U; Women's Cancer, University College London Elizabeth Garrett Anderson Institute for Women's Health, London, United Kingdom., Modugno F; Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania. Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania., Moysich KB; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York., Narod SA; Women's College Research Institute, Toronto, Ontario, Canada., Nedergaard L; Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Ness RB; The University of Texas School of Public Health, Houston, Texas., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland., Odunsi K; Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York., Olson SH; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Orlow I; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Orsulic S; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Weber RP; Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina., Pearce CL; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Pejovic T; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Pelttari LM; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, HUS, Finland., Permuth-Wey J; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Phelan CM; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Pike MC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Poole EM; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts., Ramus SJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Rosen B; Department of Gynecologic-Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Rossing MA; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Epidemiology, University of Washington, Seattle, Washington., Rothstein JH; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California., Rudolph A; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Runnebaum IB; Department of Gynecology, Jena University Hospital, Friedrich Schiller University, Jena, Germany., Rzepecka IK; Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Salvesen HB; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Schildkraut JM; Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina. Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina., Schwaab I; Institut für Humangenetik Wiesbaden, Wiesbaden, Germany., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Shvetsov YB; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii., Siddiqui N; Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom., Sieh W; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California., Song H; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Southey MC; Department of Pathology, University of Melbourne, Parkville, Victoria, Australia., Sucheston-Campbell LE; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York., Tangen IL; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Teo SH; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia., Terry KL; Obstetrics and Gynecology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Harvard School of Public Health, Boston, Massachusetts., Thompson PJ; Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California., Timorek A; Department of Obstetrics, Gynecology, and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland., Tsai YY; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Tworoger SS; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts., van Altena AM; Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands., Van Nieuwenhuysen E; Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium., Vergote I; Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium., Vierkant RA; Department of Health Science Research, Mayo Clinic, Rochester, Minnesota., Wang-Gohrke S; Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany., Walsh C; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Whittemore AS; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California., Wicklund KG; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Wilkens LR; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii., Woo YL; University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia., Wu X; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wu A; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Yang H; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Ziogas A; Department of Epidemiology, Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, California., Sellers TA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Monteiro AN; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Freedman ML; Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Gayther SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Pharoah PD; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2015 Oct; Vol. 24 (10), pp. 1574-84. Date of Electronic Publication: 2015 Jul 24.
DOI:	10.1158/1055-9965.EPI-14-1270
Abstrakt:	Background: Genome-wide association studies (GWAS) have so far reported 12 loci associated with serous epithelial ovarian cancer (EOC) risk. We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations. Methods: We selected TF genes within 1 Mb of the top signal at the 12 genome-wide significant risk loci. Mutual information, a form of correlation, was used to build networks of genes strongly coexpressed with each selected TF gene in the unified microarray dataset of 489 serous EOC tumors from The Cancer Genome Atlas. Genes represented in this dataset were subsequently ranked using a gene-level test based on results for germline SNPs from a serous EOC GWAS meta-analysis (2,196 cases/4,396 controls). Results: Gene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05). These results were replicated (P < 0.05) using an independent association study (7,035 cases/21,693 controls). Genes underlying enrichment in the six networks were pooled into a combined network. Conclusion: We identified a HOX-centric network associated with serous EOC risk containing several genes with known or emerging roles in serous EOC development. Impact: Network analysis integrating large, context-specific datasets has the potential to offer mechanistic insights into cancer susceptibility and prioritize genes for experimental characterization. (©2015 American Association for Cancer Research.)
Databáze:	MEDLINE
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