Atomoxetine accelerates attentional set shifting without affecting learning rate in the rat.
| Autor: | Totah NK; Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstr. 38, 72076, Tuebingen, Germany, nelson.totah@tuebingen.mpg.de., Logothetis NK, Eschenko O |
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| Jazyk: | angličtina |
| Zdroj: | Psychopharmacology [Psychopharmacology (Berl)] 2015 Oct; Vol. 232 (20), pp. 3697-707. Date of Electronic Publication: 2015 Jul 24. |
| DOI: | 10.1007/s00213-015-4028-5 |
| Abstrakt: | Rationale: Shifting to a new rule is a form of behavioral flexibility that is impaired in numerous psychiatric and neurological illnesses. Animal studies have revealed that this form of flexibility depends upon norepinephrine (NE) neurotransmission. Atomoxetine, a NE reuptake inhibitor, improves performance of humans in set shifting tasks. Objective: Our objective was to validate its effects in a rodent set shifting task. Methods: We tested the drug effect using an operant task that required a shift from a visual cue-guided behavior to a novel location-guided rule. Results: A 1.0-mg/kg dose significantly accelerated rule shifting without affecting learning strategies, such as win-stay or lose-shift. Fitting behavioral performance with a learning function provided a measure of learning rate. Conclusion: This novel analysis revealed that atomoxetine accelerated shifting to the new rule without affecting learning rate. |
| Databáze: | MEDLINE |
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