Comparative immunohistochemical expression of β-catenin, EGFR, ErbB2, and p63 in adamantinomatous and papillary craniopharyngiomas.
| Autor: | Esheba GE; Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt. Electronic address: ghadaesheba@yahoo.com., Hassan AA; Department of Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2015 Sep; Vol. 27 (3), pp. 139-45. Date of Electronic Publication: 2015 Jul 18. |
| DOI: | 10.1016/j.jnci.2015.06.003 |
| Abstrakt: | Unlabelled: Craniopharyngiomas (CPs) are rare epithelial tumors located mainly in the sellar/parasellar region. CPs have been classified into histopathologically, genetically, clinically and prognostically two distinctive subtypes: adamantinomatous and papillary variants. Aim: To determine the immunohistochemical expression of β-catenin, EGFR, ErbB2, and p63 in adamantinomatous and papillary CPs. Materials and Methods: β-Catenin, EGFR, ErbB2, and p63 immunostaining was performed on paraffin embedded tissue sections of 25 CPs including 18 adamantinomatous craniopharyngioma (ACP) and 7 cases of papillary craniopharyngiomas (PCPs). Results: 17 cases (94%) of ACP exhibited strong nuclear/cytoplasmic expression of β-catenin. On the contrary, all cases of PCP showed exclusively membranous expression (P value<0.0001). Regarding EGFR, 15 (83%) and 5 cases (71%) of APC and PCP respectively were positive. On the other hand, only 3 cases (17%) of APC and none of PCP exhibited positivity for ErbB2. p63 over-expression was observed in 16 cases of ACP (89%) and 6 cases of PCP (86%). However, the distribution of p63 staining was diffuse in ACP, while in PCP; the staining was mainly restricted to the basal cell layer. Conclusion: Nuclear accumulation of β-catenin is a diagnostic hallmark of the ACP and is very helpful in the differential diagnosis between both ACP and PCP in the setting of small biopsies. Moreover, the restricted nuclear β-catenin accumulation in the cohesive cell clusters within the whorl-like areas supports that aberrant β-catenin expression may play a role in the morphogenesis of ACP. (Copyright © 2015 The Authors. Production and hosting by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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