Serial optical coherence tomography imaging of ACS-causing culprit plaques.
| Autor: | Souteyrand G; Department of Cardiology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Arbustini E, Motreff P, Gatto L, Di Vito L, Marco V, Amabile N, Chisari A, Kodama T, Romagnoli E, Tavazzi L, Crea F, Narula J, Prati F |
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| Jazyk: | angličtina |
| Zdroj: | EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2015 Jul; Vol. 11 (3), pp. 319-24. |
| DOI: | 10.4244/EIJV11I3A59 |
| Abstrakt: | Aims: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. Methods and Results: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque. Conclusions: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque. |
| Databáze: | MEDLINE |
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