Effects of long-term low-dose dietary creatine supplementation in older women.

Autor: Lobo DM; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil., Tritto AC; School of Physical Education and Sport, Universidade de São Paulo, Brazil., da Silva LR; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil., de Oliveira PB; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil., Benatti FB; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil., Roschel H; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil; School of Physical Education and Sport, Universidade de São Paulo, Brazil., Nieß B; AlzChem AG, Germany., Gualano B; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil; School of Physical Education and Sport, Universidade de São Paulo, Brazil. Electronic address: gualano@usp.br., Pereira RM; Bone Laboratory Metabolism, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Experimental gerontology [Exp Gerontol] 2015 Oct; Vol. 70, pp. 97-104. Date of Electronic Publication: 2015 Jul 17.
DOI: 10.1016/j.exger.2015.07.012
Abstrakt: Objective: We aimed to investigate the effects of a one-year low-dose creatine supplementation trial on bone health, lean mass, and muscle function in older postmenopausal women.
Methods: A double-blind, randomized, parallel-group, placebo controlled trial was conducted between November 2011 and November 2013 in Sao Paulo, Brazil. Postmenopausal osteopenic women were randomly allocated (1:1) into creatine (n=56; 1g/d) or placebo group (n=53; dextrose at same dose). At baseline and after one year of intervention, we assessed parameters of bone health, body composition, and muscle function. Blood parameters were also assessed before and after the intervention and adverse events were recorded throughout the trial. Possible differences in dietary intake were assessed by three 24-h dietary recalls.
Results: Bone mineral density at lumbar spine, femoral neck, total femur, and whole body did not differ within- or between-groups. No significant changes in body weight, BMI, absolute and relative body fat, and body lean mass were observed. Muscle function, as assessed by timed-up-and-go and timed-stands tests, were not significantly changed within- or between-groups. Safety laboratory parameters remained unaltered.
Conclusion: A one-year low-dose creatine supplementation (1g/d) was free of adverse effects, but did not affect bone health parameters, lean mass, or muscle function in older women. Further studies with longer follow-up periods and higher doses of creatine supplementation are warranted. (Registered at clinicaltrials.gov as NCT01472393).
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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