Candida albicans the chameleon: transitions and interactions between multiple phenotypic states confer phenotypic plasticity.

Autor: Scaduto CM; Brown University, 171 Meeting St, Providence, RI 02912, United States., Bennett RJ; Brown University, 171 Meeting St, Providence, RI 02912, United States. Electronic address: Richard_Bennett@brown.edu.
Jazyk: angličtina
Zdroj: Current opinion in microbiology [Curr Opin Microbiol] 2015 Aug; Vol. 26, pp. 102-8. Date of Electronic Publication: 2015 Jul 17.
DOI: 10.1016/j.mib.2015.06.016
Abstrakt: The ability of microbial cells to exist in multiple states is a ubiquitous property that promotes adaptation and survival. This phenomenon has been extensively studied in the opportunistic pathogen Candida albicans, which can transition between multiple phenotypic states in response to environmental signals. C. albicans normally exists as a commensal in the human body, but can also cause debilitating mucosal infections or life-threatening systemic infections. The ability to switch between cellular forms contributes to C. albicans' capacity to infect different host niches, and strictly regulates the program of sexual mating. We review the unique properties associated with different phenotypic states, as well as how interactions between cells in different states can further augment microbial behavior.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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