Attention Deficit Hyperactivity Disorder and oxidative stress: A short term follow up study.

Autor: Guney E; Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey. Electronic address: dresraguney@gmail.com., Cetin FH; Kayseri Training and Research Hospital, Department of Child and Adolescent Psychiatry, Kayseri, Turkey., Alisik M; Yildirim Beyazit University Medical Faculty, Atatürk Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey., Tunca H; Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey., Tas Torun Y; Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey., Iseri E; Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey., Isik Taner Y; Gazi University Medical Faculty, Child and Adolescent Psychiatry Department, Ankara, Turkey., Cayci B; Gazi University Medical Faculty, Department of Medical Biochemistry, Ankara, Turkey., Erel O; Yildirim Beyazit University Medical Faculty, Atatürk Training and Research Hospital, Department of Medical Biochemistry, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2015 Sep 30; Vol. 229 (1-2), pp. 310-7. Date of Electronic Publication: 2015 Jul 08.
DOI: 10.1016/j.psychres.2015.07.003
Abstrakt: In this study, we aimed to investigate total antioxidative status (TAS) and total oxidative status (TOS) of plasma and antioxidant enzymes such as paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARES) and thiols in plasma of children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD). In the second step. this study aimed to reveal the possible effects of ADHD treatment on these parameters. Fifty-six patients with ADHD and 52 healthy controls were involved in this study. Venous blood samples were collected and oxidative and antioxidative parameter's were studied. In the second phase of the study, blood samples were taken from patients using medication. Pre-treatment oxidative stress index (OSI) values and the plasma TOS levels of the patients with ADHD were statistically higher than those of the control group. The plasma thiol levels of the patients with ADHD were significantly lower than the control group. The post-treatment plasma antioxidative parameter's levels were significantly higher than the pre-treatment levels. The post-treatment oxidative stress index value was significantly lower than the pre-treatment value. Therefore, oxidative metabolism was found to be impaired in children and adolescents with ADHD. It was also determined that methylphenidate repairs the oxidative balance by increasing antioxidant defence mechanisms.
(Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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