Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery.

Autor: Pakulska MM; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.; Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada., Vulic K; Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON, M5S 3H6, Canada., Tam RY; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.; Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada., Shoichet MS; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.; Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada.; Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON, M5S 3H6, Canada.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2015 Sep 09; Vol. 27 (34), pp. 5002-8. Date of Electronic Publication: 2015 Jul 16.
DOI: 10.1002/adma.201502767
Abstrakt: Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long-lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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