Gender differences in prognostic factors for oral cancer.
Autor: | Honorato J; Pathology Graduate Program, Fluminense Federal University (UFF), Niteroi, RJ, Brazil., Rebelo MS; Information Division, Brazilian Cancer Institute, Rio de Janeiro, RJ, Brazil., Dias FL; Department of Head and Neck Surgery, Brazilian Cancer Institute, Rio de Janeiro, RJ, Brazil., Camisasca DR; Dentistry School of Nova Friburgo, Fluminense Federal University (UFF), Niteroi, RJ, Brazil., Faria PA; Department of Pathology, Brazilian Cancer Institute, Rio de Janeiro, RJ, Brazil., Azevedo e Silva G; Social Medicine Institute, Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil., Lourenço SQ; Pathology Graduate Program, Fluminense Federal University (UFF), Niteroi, RJ, Brazil. Electronic address: silourenco@br.inter.net. |
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Jazyk: | angličtina |
Zdroj: | International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2015 Oct; Vol. 44 (10), pp. 1205-11. Date of Electronic Publication: 2015 Jul 14. |
DOI: | 10.1016/j.ijom.2015.04.015 |
Abstrakt: | The aim of this study was to assess gender differences in prognostic factors among patients treated surgically for oral squamous cell carcinoma (OSCC). The medical records of 477 eligible patients (345 males, 132 females) obtained from the Brazilian Cancer Institute were reviewed. Survival was calculated by Kaplan-Meier method. Cox regression models were used to obtain adjusted hazard ratios (aHR) for males and females. Multivariate analysis showed that past tobacco use (aHR 0.2, 95% confidence interval (CI) 0.1-0.7) and regional metastasis (aHR 2.3, 95% CI 1.5-3.5) in males, and regional metastasis (aHR 2.2, 95% CI 1.2-4.3), distant metastasis (aHR 6.7, 95% CI 1.3-32.7), and hard palate tumours (aHR 11.8, 95% CI 3.3-47.7) in females, were associated with a higher risk of death. There were no differences in survival between males and females. Regional metastasis was found to be a negative prognostic factor in OSCC for both genders. Past tobacco use was an independent prognostic factor for worse survival among males, while distant metastasis and hard palate tumours were independent prognostic factors for worse survival among females. Further studies are necessary to corroborate the relationships found in this study. (Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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