High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014.

Autor: Farag EA; Supreme Council of Health, Doha, Qatar., Reusken CB; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands; c.reusken@erasmusmc.nl., Haagmans BL; Supreme Council of Health, Doha, Qatar., Mohran KA; Animal Resources Department-Ministry of Environment, Doha, Qatar., Stalin Raj V; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands., Pas SD; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands., Voermans J; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands., Smits SL; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands., Godeke GJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Al-Hajri MM; Supreme Council of Health, Doha, Qatar; malhajri1@sch.gov.qa., Alhajri FH; Animal Resources Department-Ministry of Environment, Doha, Qatar., Al-Romaihi HE; Supreme Council of Health, Doha, Qatar., Ghobashy H; Animal Resources Department-Ministry of Environment, Doha, Qatar., El-Maghraby MM; Animal Resources Department-Ministry of Environment, Doha, Qatar., El-Sayed AM; Supreme Council of Health, Doha, Qatar., Al Thani MH; Supreme Council of Health, Doha, Qatar., Al-Marri S; Supreme Council of Health, Doha, Qatar., Koopmans MP; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Jazyk: angličtina
Zdroj: Infection ecology & epidemiology [Infect Ecol Epidemiol] 2015 Jul 15; Vol. 5, pp. 28305. Date of Electronic Publication: 2015 Jul 15 (Print Publication: 2015).
DOI: 10.3402/iee.v5.28305
Abstrakt: Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.
Databáze: MEDLINE
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